Profiles are derived from Role Gates found in both the G Center and the Sacral Center. These Gates make up the core of the six archetypes that are profiled in Human Design: the Investigator, Heretic, Opportunist, Hermit, Martyr and Role Model.

Following the 36 Roles — a 3-part course on Profiling — Ra added a final lecture on the two Gates that represent the essence of our survival, intelligence and emotional awareness: Gate 50 in the Splenic Center, and Gate 6 in the Solar Plexus Center.

The Guardian and the Builder is a 1-hour 15-minute lecture detailing the importance of Gate 50 and Gate 6 in the evolution of humanity, and in influencing the expression of individual Profile.