This antibody portfolio includes a wide range of tissue- & tumor-specific primary antibodies for basic research, product development and analysis of a variety of biological questions. The monoclonal antibodies are perfectly applicable for all cell or tissue biology studies and for the analysis of predictive markers in research.

Perilipins build a family of phosphoproteins. The predominant forms in adipocytes, PLIN1 A and B arise by alternative RNA splicing from a single gene, generating polypeptides of 57 kDa and 46 kDa, respectively. The N-terminus, however, remains unchanged. The antibody reacts specifically with all PLIN1 variants located at the surface of intracellular storage lipid droplets present e.g. in the adrenal gland, sebaceous gland, adipocytes of white and brown adipose tissue and cultured cells such as 3T3-L1 adipocytes and cultured steroidogenic adrenal cortical and Leydig cells. It is also a useful pathological marker for steatogenesis e.g. in liver. It does not cross-react with adipophilin (ADRP, also named PLIN2) or TIP47 (also named PLIN3) proteins (or additional members of the PLIN/PAT-family, e.g. MLDP or OXPAT/PAT-1, also named PLIN5 or LSDP5). Tested reactivity on cultured cell lines: several human carcinoma cell lines; 3T3-L1 adipocytes.

Immunocytochemistry (ICC): assay dependentImmunohistochemistry (IHC) - frozen: 1:200 (0.5 μg/ml)Immunohistochemistry (IHC) - paraffin: 1:200 (0.5 μg/ml, microwave treatment recommended)