Dimethoxytrityl is a protective group for hydroxy groups which is used to protect the 5' OH group of the individual nucleotides in DNA synthesis. The protective group is acid labile and is removed in the ongoing synthesis reaction by the addition of trifluoroacetic acid (deprotection) to enable the coupling of the subsequent nucleotide.

We offer DMT-Removal-Reagent in dichloroethane (K060) as well as in dichloromethane (2257). DMT in DCE is used for synthesizers which draw the solution from the bottles by vacuum pumps and push it through the reaction columns. Since these vacuum pumps apply a significant force, the DCE is more suitable due to its high boiling pressure, as it is absorbed and introduced into the reaction without the formation of gas bubbles. The use of DMT in DCM could interfere with the reaction by creating gas bubbles.